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PubMed Central , Neuropsychopharmacology Reports , vol

Ferroptosis-inducing factors can directly or indirectly affect glutathione peroxidase through different pathways, resulting in a decrease in antioxidant capacity and accumulation of lipid reactive oxygen species (ROS) in cells, ultimately leading to oxidative cell death

Problems with any of these processes may contribute to male-factor infertility

R., Khan M., Kuniyil M., Al-Warthan A., Alkhathlan H

Free Radic Biol Med 126:5566 Zhao R, Masayasu H, Holmgren A (2002) Ebselen: a substrate for human thioredoxin reductase strongly stimulating its hydroperoxide reductase activity and a superfast thioredoxin oxidant

Rats were acclimatized to a controlled environment of 22 1 C temperature and a 12-h light/dark cycle, with free access to food and water, for 2 weeks prior to the experiments