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In these cases, consistency is presumed

demonstrated that lipid nanoparticles possess intrinsic adjuvant activity independent of their mRNA cargo, eliciting strong T follicular helper cell responses and durable antibody production (147)

doi: 10.3174/ajnr.A7691 11 TerryMWakemanKWilliamsBJMillerDMSakMAbdullaevZet al

Intraoperative radiotherapy (IORT) or more aggressive surgical strategiessuch as sacrificing involved nerve rootsmay be necessary to improve local control ( Although surgery remains the primary curative modality, the clinical benefit of adjuvant radiotherapy and chemotherapy remains controversial

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But neither of these examples are very "real world"