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Several preclinical investigations have proven the anti-inflammatory properties of silymarin through inhibiting NF-B activation, reduction of hepatic tumor necrosis factor alpha (TNF-), malondialdehyde (MDA) levels and transforming growth factor- (TGF-) mRNA expression, as well as preventing the generation of inflammatory metabolites such as prostaglandin E2 (PGE2) and leukotriene B4 (LTB4) [116,117,118,119,120]

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[DOI] [PubMed] [Google Scholar] 209.Zhao G, Souers AJ, Voorbach M, et al

Hatori, M

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Clinical observation of atorvastatin combined with Qianggu capsules in the elder patients with type 2 diabetic osteoporosis