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L.GalabertC.HoudretN.DegandP.et al (1984)

There are specific conditions needed for an efficient ADCC or CDC, including enough number of antibodies attached to the target cell, a sufficient number of effector immune cells (such as natural killer [NK] cells, monocytes, and granulocytes), and the absence of ADCC suppressor cells (such as regulatory T cells [Tregs] and myeloid-derived suppressor cells [MDSCs]) in the tumor microenvironment

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[65] demonstrated that bevacizumab, an anti-VEGF antibody, has efficacy in RCC, and over the past several years, there has been an increase in progression-free survival and quality of life in patients with metastatic RCC, which was attributed to the advent of the MTKIs [66, 67]

This is where advanced interventions like LDN and peptide therapy come in, offering a more direct and targeted approach to address these core issues