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The germ-free animals presented lower levels of IL-6 and TNF- than the corresponding controls, and lower levels of ROS and less macrophage infiltration in the DRG, whilst these differences were not observed in the spinal cord and the major immune cells in peripheral blood were unaffected

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[DOI] [PubMed] [Google Scholar] Miguez A

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Additionally, the dense cartilage ECM and rapid synovial fluid turnover hinder exosome retention and uptake