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This review aims to provide a comprehensive overview of the phytochemicals targeting the L-arginine/NO/cGMP/K ATP pathway, elucidating their mechanisms of action, therapeutic applications, and clinical perspectives in cardiovascular health, metabolic disorders, pain management, and other physiological functions

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TB 500 binds to G-actin, preventing its polymerization into F-actin (filamentous actin) and thereby maintaining a pool of free actin available for cellular motility and migration a process critical to wound healing and regeneration

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This pathway is particularly significant in the liver and kidney, where dietary betaine and choline intake can directly influence methionine cycling efficiency