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May 16 2024;14(1):29

Methionine contributes to synthesizing other essential amino acids, such as Cysteine (Cys), and to the supply of methyl (CH 3 ) donors in the one-carbon cycle (Lauinger and Kaiser, 2021), as well as supporting to phospholipid homeostasis (Li and Vance, 2008)

Thus, several efforts are being made to develop innovative approaches to repair or ideally regenerate IVDs original morpho-functional features

28,29 In this regard, it is notable that astrocyte reactivity is an ancient response among vertebrates and has been essentially conserved across over 100 million years of divergent mammalian evolution that separate rodents, carnivores, herbivores and primates including humans

Biometals 34 , 221228 (2021)

This approach reduces inflammation and may lower the required doses of traditional anti-inflammatory medications [110]