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The GSH depletion was the earliest event in BSO plus HCH-induced signaling and the apoptotic effect of this combination was correlated with the enhanced depletion of GSH as glutathione precursor GME abrogated activation of JNK, ERK and the apoptosis

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Emerging evidence indicates that reactivation of oncogenic signaling pathways is frequently accompanied by parallel reprogramming of metabolic networks, forming a coordinated dual-track mechanism of resistance driven by signaling-metabolism crosstalk [75]

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