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Elevated levels of serum Interleukin-8 (IL-8) in T1DM individuals with poor glucose control may contribute to an inflammatory response that has shown to lower IGF-1 levels in chronic inflammatory diseases [74]

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Continuous copper peptide exposure for 6+ weeks without rest periods upregulates MMPs beyond the healthy remodeling threshold

In fibrosis, the ECM becomes excessively stiff due to the increased collagen deposition and cross-linking [16]

Atherosclerotic burden and cerebral small vessel disease: exploring the link through microvascular aging and cerebral microhemorrhages