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There were no toxicities of grade 2 or more by World Health Organization (WHO) criteria at the 0.16 mg/kg dose, whereas the two higher doses produced moderate gastrointestinal upset and some mild to moderate fatigue Another study involved combining Melanotan 1 with either sunlight exposure or selective application of UV-B, and it turns out the peptide works synergistically with both methods: Tanning in the first study was achieved in 3 of 4 subjects receiving MT-1, and these subjects also had 47% fewer sunburn cells at the irradiated neck site [Daily Melanotan I use mixed with UV-B exposure to neck More skin sites darkened with the higher dose of MT-1 in the second study [Daily Melanotan I use mixed with UV-B exposure to the buttocks] In the third study, there was significantly enhanced tanning of the back in the MT-1 group, and this was maintained at least 3 weeks longer than the tanning in the sunlight-only controls, who required 50% more sun-exposure time for equivalent tanning [Daily Melanotan I use mixed with sunlight exposure to the back] Not only does Melanotan 1 work incredibly well on very fair-skinned people, but it also offers protective effects to the skin against harmful UV light damage: We have recently completed a doubleblind, randomized controlled study in 80 healthy Caucasian adult subjects

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