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When considering the cellular response as a whole, HO-1 acts as a hub of gene-gene interactions that modulate the triggering and activation of several protective molecular pathways
91 , e0239916 (2017)
Furthermore, as a cyto-protectant, melatonin helps alleviate several COVID-19 comorbidities, including T2DM, metabolic syndromes, and both ischemic as well as non-ischemic CVD 657
Exercise therapy, particularly resistance training, derives part of its benefits from regulating chronic inflammation and oxidative stress
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