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This binding switches 15LO1s preferred substrate from free arachidonic acid to arachidonic acid conjugated to PE, which generates ferroptotic lipids, including the hydroperoxy-phospholipid 15-hydroperoxy-eicosatetraenoic acidPE (15-HpETE-PE) (6, 7, 10, 13)

Studies show carnitine deficiencythough rare in healthy adultscorrelates with reduced exercise-induced fat loss and slower metabolic adaptation

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doi:10.1038/s41575-021-00440-6 Ananda Rao A, Johncy S

It stimulates the synthesis of key extracellular matrix components while neutralizing reactive oxygen species, restoring firmness and reducing oxidative damage that accelerates visible and molecular aging