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AOD-9604 Research Protocols & Administration Dosing in Published Research Research investigations have employed diverse AOD-9604 doses across species and administration routes: Rodent studies: 250-500 mcg/kg orally or intraperitoneally was most common for obesity research Rabbit models: 0.25 mg per joint for osteoarthritis studies (intra-articular injection) Pig pharmacokinetic studies: 1.5 mg/kg IV and 2 mg/kg oral for metabolism characterization Human clinical trials: Oral doses of 0.25-10 mg daily

M2a macrophages are predominantly activated by IL-4 and IL-13, which are critical mediators of allergic inflammation

(Academic, 2023)

Orally bioavailable lead candidates will be tested in a comprehensive doseranging study to confirm efficacy on obesity and co-morbid endpoints

Hands require washing after application to prevent unwanted facial hair growth, particularly important for women

Orders are shipped domestically within Australia