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Mapping the spreading routes of lymphatic metastases in human colorectal cancer
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Given the essentiality of the IRP-IRE system to the maintenance of iron homeostasis, and the growing body of evidence implicating the key players of this system in ferroptotic cell death, delineating the specific roles of IRP1 and IRP2 in ferroptosis is of fundamental importance to fully harness its chemotherapeutic potential
A diverse range of sphingolipids has been identified in the nervous system as essential components of cellular membranes, and they play critical roles in maintaining brain function, particularly neurogenesis and synaptogenesis 4,67
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