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36 KimY

Indeed the beneficial effect of non-steroidal anti-inflammatory drugs (NSAIDS) in colorectal cancer prevention and therapy has been attributed partially to the perturbation of TCF/-catenin signaling through the ability of NSAIDS to inhibit Prostaglandin E2 production, which enhances TCF/-catenin-dependent transcription (Castellone et al., 2005

Lee H, Shi W, Tontonoz P, Wang S, Subbanagounder G, Hedrick CC, Hama S, Borromeo C, Evans RM, Berliner JA, Nagy L

The treatment provides lasting results since it resolves the main cause of discoloration

715,716 This protective mechanism, which promotes cell proliferation and immune evasion, is similarly observed in HCV infection and may contribute to cancer susceptibility

Recommendations Given the importance of renal recovery and the requirement for rapid serum FLC reduction, an aggressive therapeutic approach is justified in patients MM patients with AKI
