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156 add up to five years to a patents life to compensate for time consumed by FDA regulatory review

Afridi HI, Talpur FN, Kazi TG, et al

Acute Symptoms: Chemical pneumonitis & non-cardiac pulmonary edema (after inhalation of metallic/elemental mercury) Severe gastroenteritis, shock, renal failure (mercury salt ingestion) Chronic Symptoms: Pink discoloration of the hands & feet & desquamation of the hands & feet (mercury vapor inhalation) Gingivitis (mercury vapor inhalation) Psychiatric disturbances ( , painful extremities, tunnel vision (mercury vapor inhalation) mad as a hatter ), irritability, tremors Nephrotoxicity, hemorrhagic gastroenteritis (inorganic mercury & ethylmercury) Perinatal exposure: mental retardation & a cerebral-palsy-type syndrome in offspring (methylmercury & possibly other forms of mercury) Treatment: Remove the source of mercury if possible ABCs Activated charcoal for GI decontamination Control diarrhea BAL - administer chelation therapy References: Olson KR (2007): Poisoning & Drug Overdose

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This pathway plays an important role in maintaining the normal cellular state by removing abnormal and damaged proteins
