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Therefore, SFN through Nrf2 pathway can promote the activation of genes that favor the mitochondrial biogenesis, thus preserving the mitochondrial complex I, II, and IV, to lead to the production of adenosine triphosphate (ATP), otherwise reduced by neuronal damage [31]

Sanderson, S

Phase 1B study of vemurafenib in combination with irinotecan and cetuximab in patients with BRAF-mutated advanced cancers and metastatic colorectal cancer 32(5s), 2014

These are the muscle-specific stem cells that donate nuclei to damaged muscle fibers, enabling both repair and growth

The section was pre-treated using heat mediated antigen retrieval with Tris-EDTA buffer (pH 8.0-8.4) for 20 minutes.The tissues were blocked in 5% BSA for 30 minutes at room temperature, washed with ddH 2 O and PBS, and then probed with the antibody (R1401-12) at 1/100 dilution, for 30 minutes at room temperature and detected using an HRP conjugated compact polymer system