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Another study shows that in the hearts of cold-blooded vertebrates, CK bound to myofibrils is necessary for fully activating myosin-ATPase activity, although their energy conversion rate is lower compared to homeothermic animals [103]
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A major mechanism of MDR involves overexpression of P-glycoprotein (Pgp) which actively extrudes drugs
Bravo JA, Forsythe P, Chew MV, et al
