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10/23-27/07 Disk degeneration and repair

Acknowledgements The authors want to express their gratitude to the Mahavir Cancer Sansthan and Research Centre in Patna, Bihar, India for providing the essential laboratory and infrastructure resources

(PubMed) Boehnke C, Reuter U, Flach U, Schuh-Hofer S, Einhaupl KM, Arnold G

Diamantopoulou Z, et al

Figure 2 2.2.1 CD8+ T cells CD8+ T cells, key immune effector cells in the TME, are involved in tumor clearance, as well as in responding to viral infections and other pathological conditions ( in vitro studies have demonstrated that glutamine deprivation can promote the differentiation of memory CD8+ T cells, facilitating the development of long-lasting immune memory ( in vivo inhibition of glutamine metabolism helps prevent CD8+ T cell exhaustion, sustaining their long-term effector functions ( 2.2.2 CD4+ T cells Upon antigenic stimulation, CD4+ T cells undergo metabolic reprogramming, activating pathways critical for their proliferation and differentiation ( via epigenetic mechanisms