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10.1016/j.biopha.2018.08.148 101

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evaluated the plasma L-carnitine levels of subjects with high levels of TMAO ( n = 2,595) and found that the intake of large amounts of L-carnitine caused cardiovascular disease (CVD) and major adverse cardiac events (MI, stroke, or death)

Another limitation was the lack of measuring the stress factors related to the hypothalamus-pituitary-adrenal axis such as corticosterone, which may have helped explain the possible neurophysiological impact of LCR supplementation

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