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The upregulation of these immunes-related pathways delineated above was attributed to the Ba/O 2 -supplied radiosensitization and multistage immune activation by sequential aCTLA-4/IL-12 release

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5mCG is mainly located at intergenic regions, repetitive DNA regions, and silenced genes, directly interfering with the binding of certain transcriptional regulators to their cognate DNA sequences or recruiting repressive methyl-CpG binding domain (MBD) proteins [33, 35]

Sustained activation of FOXO1 results in increased hepatic glucose production and insulin resistance

PECAM-1 directed re-targeting of exogenous mRNA providing two orders of magnitude enhancement of vascular delivery and expression in lungs independent of apolipoprotein E-mediated uptake

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