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Production of [14C]carbon dioxide by 1 mL erythrocytes incubated for 1 hour with 10 mmol /L [14C-1]glucose at 10 Ci /mmol

Since less than 10% of its clearance is attributed to vareniclines metabolism, it is anticipated that agents affecting the CYP450 system will have no effect on its pharmacokinetic profile

Based on limited human pharmacology data, ipamorelin appears relatively selective, with less pronounced effects on cortisol and prolactin secretion compared with some other GH secretagogues though this selectivity has not been extensively validated in large human trials

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10.1016/j.exger.2014.10.002 5 AyyarV

131 , e140521 (2021)