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alcohol dehydrogenase and more importantly Acetaldehyde are the issues i took NAC (Jarrows 600 mg sustained release, on amazon) 3X daily for about 10 days prior to having an alcoholic beverage and my reaction (feeling very drunk from 2-3 drinks which lasted hours on end, poor sleep, horribly hungover) was gone

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In mild cases, low levels of vitamin B12 can cause fatigue and anemia, while more serious deficiencies can lead to serious neurological and heart impairments