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Non-pharmacological options, such as cognitive behavioral therapy and non-invasive brain stimulation NIBS, could improve evidence of efficacy and lead to relevant improvement in FM-related disability.

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Combined treatment of l-carnitine and metformin significantly decreased the number of squares crossed in OFT as compared to l-carnitine-alone-treated diabetic rats and significantly increased the time spent at the center of the open field as compared to untreated diabetic rats and metformin-alone and l-carnitine-alone-treated diabetic rats

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