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Oral Supplements: Generally take longer to show noticeable results, especially if absorption is compromised

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Blood glucose improvements can be detected within the first week of treatment in patients with type 2 diabetes

The 3 mL vials are more convenient

Methods/design Study type This study takes the form a pragmatic, randomised, multicentre, non-inferiority clinical trial undertaken in the primary healthcare setting, with a duration of one year

Patients with severe deficiency may need more frequent injections initially, while those using B12 for wellness optimization may maintain results with monthly treatments