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Studies with mutants and transgenic plants over- or under-expressing enzymes or metabolites of the AsA-GSH pathway have proved very well the co-relation between this pathway and stress tolerance (Gill and Tuteja, 2010)

doi: 10.1016/j.febslet.2004.05.044

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Similarly, tolvaptan, the only FDA approved drug for autosomal dominant polycystic kidney disease (ADPKD), is difficult to tolerate due to side effects such as nausea and polyuria, and has been found to cause hepatotoxicity in certain patients [14]

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