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When the water-soluble Glu moiety in TB m A-Glu is cleaved by GGT, it triggers the aggregation of insoluble TB m A

References: Andersson KE, Arner A (2004): Urinary Bladder Contraction and Relaxation: Physiology and Pathophysiology

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doi:10.3760/cma.j.issn.1009-2587.2019.08.014

J.AllaeysV.Buc CalderonP.StevignyC.BigendakoM

However, clinical trials with T4 gels at various concentrations (0.01, 0.02, 0.03, and 0.1%) in patients with pressure ulcers, venous leg ulcers, and epidermolysis bullosa showed no statistically significant difference in healing as compared to that of placebo, although some trends towards faster healing were noted at intermediate doses during early weeks [242,243]