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Withdrawal rates due to adverse effects serve as a practical measure of real-world tolerability, as they reflect whether side effects are bothersome enough to outweigh potential benefits

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18 Table 4 Time to Improvement of Abnormalities in Vitamin B12 Deficiency After Initiation of Treatment A 2005 Cochrane review involving 108 patients with vitamin B 12 deficiency found that high-dose oral replacement (1 mg to 2 mg per day) was as effective as parenteral administration for correcting anemia and neurologic symptoms

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The results show further investigation into ICA-1s as a therapeutic is warranted to assess the potential for progress toward clinical trials