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References 1.Meister A., Anderson M.E
Nature 365 , 797805 (1993)
This is significant as complex III is the final protein complex within the mitochondria for the transfer of electrons to complex IV
10.1172/JCI6223
Humans show this age-related NAD+ decrease in their liver, skin, brain, plasma, skeletal muscle, and monocyte-derived macrophages
This means that ALA is easily absorbed through the lipid layers of the skin and works equally well as a free-radical fighter in the cell plasma membrane and in the watery interiors of the cell
