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Trexler and SmithRyan 2015 )

279 , L895L902 (2000)

doi: 10.3390/jcm5070065
Pradhan et al., 2022

Data from the National Survey on Drug Use and Health revealed that 80% of new heroin users previously abused prescription opioids, indicating a link between prescription analgesic misuse and heroin use.32 Tolerance significantly reduces the analgesic efficacy of opioids in patients with substance use disorders

Choline transporters, cholinergic transmission and cognition