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Recently, researchers have found that excessive mast cell degranulation in the joints is the cause of osteoarthritis.[ref] To prove this, researchers looked at both human joints and genetic models using mice

178 , R267R280 (2018)

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Data from semaglutide discontinuation studies shows that approximately two-thirds of lost weight returns within one year of cessation

If confirmed, this could redefine therapeutic strategies for metabolic diseasetargeting the inflamed hypothalamus as the origin rather than the consequence of systemic dysfunction