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235 H 2 O 2 also increases threonine phosphorylation in Caco-2 cells by downregulating PP2A via oxidation of its redox-sensitive Cys266 and Cys269, forming inhibitory disulfide bonds, 236 particularly through oxidation of the B55 isoform

The N-terminal functional domain is the binding site for GSH and is therefore referred to as the G site

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Biol Trace Elem Res 24:109117 Mischley LK, Conley KE, Shankland EG, Kavanagh TJ, Rosenfeld ME, Duda JE, White CC, Wilbur TK, De La Torre PU, Padowski JM (2016) Central nervous system uptake of intranasal glutathione in Parkinson's disease