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The pooled effect size in CRC patients was not significantly lower than that in the control group at the 99% confidence level (WMD (99% CIs) = 5.40 (44.45, 33.65), p = 0.722) (Fig

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While IGF-1 levels may exhibit minimal diurnal fluctuation, they are influenced by a number of other biological factors including age and pubertal stage, BMI extremes, pregnancy and to a lesser but still significant degree, sex and ethnicity

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In the near future, we are likely to see increasingly sophisticated preclinical models of irAEs, risk stratification with irAE biomarkers, and evidence based approaches for the management of irAE subsets such as steroid-refractory disease (Fig