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It works by first separating compounds using gas chromatography and then detecting them based on their mass spectra

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Ledipasvir and Sofosbuvir for Untreated HCV Genotype 1 Infection Published May 15, 2014 N Engl J Med 2014;370:1889-1898 DOI: 10.1056/NEJMoa1402454 Abstract Background In phase 2 studies, treatment with the all-oral combination of the nucleotide polymerase inhibitor sofosbuvir and the NS5A inhibitor ledipasvir resulted in high rates of sustained virologic response among previously untreated patients with hepatitis C virus (HCV) genotype 1 infection

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Nevertheless, therapeutic hypothermia is only partially effective (5760), and many infants with HIE remain at substantial risk of death or severe long-term neurodevelopmental impairments (55)