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Known as the sunshine vitamin, Many people are deficient due to limited sun exposure, dietary gaps, or lifestyle factors, which can lead to fatigue, low immunity, and weakened bones

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After activation of the ULK1 complex, PIKfyve Ser1548 is phosphorylated to promote the conversion of PI to PI(5)P, with the latter subsequently binding WIPI2 to promote separation of the isolation membrane from the ER membrane [2, 17, 18]

When these receptors activate, fat cells release stored lipids for energy use

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J Biol Chem 289:2149021507