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[3] described three dominant hypotheses of HH, which are as follows: (1) increased intra-abdominal pressure that moves the gastroesophageal junction into the thorax cavity, (2) esophageal shortening from innate causes or acquired caused by fibrosis, and (3) widening of the orifice from innate or acquired changes in the crural muscles or connective tissue of the diaphragm

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The physiological and toxicological properties of this chemical have not been fully investigated

Vitamin B 12 is crucial for neurologic function, red blood cell production, and DNA synthesis, and is a cofactor for three major reactions: the conversion of methylmalonic acid to succinyl coenzyme A

The search included meta-analyses, randomized controlled trials, clinical trials, and systematic reviews