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It binds to GABA receptors, promoting relaxation and reducing stress-related cognitive symptoms

NRF2 can also prevent IL-6 expression by ARE-dependent induction of ATF3 that suppresses IL-6 transcription [128,129]

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The parents were exposed to this concept by reading popular books on the topic of total allostatic load and autism [158], listening to autism-focused audio materials [156] provided by their coach, and subsequently taking the Child Health Inventory for Resilience and Prevention (CHIRP) survey of the Documenting Hope Project, a comprehensive assessment of total allostatic load among children [161]

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Indeed, in addition to HbS polymerization, an imbalance in redox status is also seen in SCD, which is caused by a rise in ROS and/or RNS generation coupled with a malfunction in the antioxidant systems