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Nevertheless, no inhibitor has yet reached phase I clinical trials and further efforts are needed to circumvent all obstacles related to absorption, metabolism and various issues on pharmacokinetics in order to eventually achieve orally bioavailable drug candidates acting as cognitive enhancers in vivo

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Although Grade 3 and 4 proteinuria reflects glomerular injury, milder grades of proteinuria may reflect either tubular or glomerular defects

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Gender-specific data were available in some studies, reporting 268 males and 288 females