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DNA methylation thus silences transposable elements while activating stress-responsive loci like CBF3 and SOS1 , as validated by WGBS across tolerant genotypes (Gupta and Garg, 2023)

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doi: 10.3109/13880200490893500

AST-IV protected microglia from lipopolysaccharide-evoked death and down-regulated the release of pro-inflammatory mediators, including interleukin IL-1 , IL-6, tumor necrosis factor (TNF- ), and nitric oxide, as well as, expression of Toll-like receptors 4 (TLR4), MyD88, and NF-B [137]

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Both have substantial published research bases, and their different mechanisms of action make them complementary rather than competing tools in tissue repair research