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Ferritin, a spherical iron storage protein in cells, is composed of a combination of 24 subunits of heavy-chain ferritin (ferritin-H) and light-chain ferritin (ferritin-L), which bind and sequester intracellular iron in the form of ferric ions[13, 56, 57]

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Inactivation of GPX4 leads to an accumulation of lipid peroxides, resulting in ferroptotic cell death

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confirmed that overexpressed SLC1A3 in gastric cancer activates the PI3K/AKT pathway, upregulates the expression levels of Glucose transporter 1 (GLUT1), Hexokinase 2 (HK2), and Lactate dehydrogenase A (LDHA), and promotes the growth of gastric cancer, while treatment with the PI3K/AKT inhibitor LY294002 could inhibit the growth-promoting effect of SLC1A3 overexpression on gastric cancer