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On reaction with hydrogen peroxide, the redox-sensitive cysteine residue of each subunit of PrxIII homodimer is oxidized to Cys-SOH, which then reacts with neighboring Cys-SH of the other subunit to form an intermolecular disulfide that can be readily reduced by Trx2 (18, 109)

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432 A 2021 systematic review and meta-analysis that included 22 observational studies with a total of 440,281 elderly participants with atrial fibrillation taking rivaroxaban, dabigatran, apixaban, or edoxaban found these medications were associated with similar reductions in risks of stroke and other embolic events, but rivaroxaban was associated with more bleeding events than apixaban or edoxaban

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