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405 Most patients with severe thalassemia experience complications of iron overload due to blood transfusions, which promote oxidative damage to various organs, leading to endocrine and ultimately organ dysfunction

An increased proportion of PUFAs in normal diet also induces oxidative stress (increased malondialdehyde [MDA]), reduces cellular defense against oxidative stress (metallothionein) in the liver, and promotes oxidative degradation of DNA (elevated 8-hydroxy-2-deoxyguanosine levels serum) in a content-dependent manner despite increased fat oxidation and decreased fat synthesis [80]

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Cepharanthine attenuates early brain injury after subarachnoid hemorrhage in mice via inhibiting 15-Lipoxygenase-1-Mediated microglia and endothelial cell ferroptosis

This gap encourages further discussion and presents opportunities for the next stage in the development of antioxidant therapies