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10.1099/mic.0.26012-0 [DOI] [PubMed] [Google Scholar] Hassan H
Under physiological conditions, reduced GSH is the major form present with a concentration 10- to 100-fold higher than the oxidized species (GSH disulfide [GSSG])
The concern was not the compound itself, but the unregulated formulations and lack of clinical oversight
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10.1038/s41467-021-22117-z Nat
Subsequently, the researchers encapsulated these uhOLN-NPs using a hypoxia-responsive polymer, resulting in NPs (HOLN-NPs) that exhibit responsiveness to both hypoxia and ROS
