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169 WuJ

Intestinal macrophages are conventionally subdivided into three subtypes (1) monocyte-derived mature macrophages, (2) monocyte-derived inflammatory macrophages, and (3) self-maintaining macrophages

Thus, targeted lactylation may be used to treat cancer, and targeted lactate production improves the tumor microenvironment, as well as preventing and improving lactylation modification to fight cancer

Activation of the RIPK3MLKL axis induces the release of DAMPs, including HMGB1, ATP, and nucleic acids, enhancing dendritic cell maturation, tumor antigen presentation, and CD8 + T-cell priming

107 Downregulation of tight junction-related proteins will loss of the BBB phenotype

DS: Writing original draft