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Preliminary results from a first-in-human study of ESG401, a trophoblast cell-surface antigen 2 (TROP2) antibody drug conjugate (ADC), in patients with locally advanced/ metastatic solid tumors

Second, a preclinical study revealed that triple blockade targeting PD-1, LAG-3, and CTLA-4 resulted in 20% tumor-free survival (TFS), whereas dual inhibition of LAG-3 and CTLA-4 in PD-1 null mice resulted in a TFS of 40%, indicating a hierarchical ordering of checkpoint functions