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This is consistent with a recent report that salvianolic acid A results in a dramatic activation of the Akt/mTOR signalling, followed by activation of the Nrf2/HO-1 axis in retinal pigment epithelia cells 60

Another reason new blood vessels are formed is the overexpression of vascular endothelial growth factor (VEGF), which can act as a hypoxia-inducible factor [84]

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1 Introduction Chlorogenic acid (CGA), also called caffeoylquinic acid (CQA), is a dietary polyphenol formed by the esterification of caffeic acid (CA) and quinic acid (QA) ( in vitro , and at 25 M, it reduces reactive oxygen species (ROS) to alleviate oxidative stress in intestinal cells ( eucommia , honeysuckle , and green tea ( The liver is vital for metabolism, the endocrine regulation, and immune response but is often exposed to irritants like viruses, medications, and chemicals ( Building on the aforementioned research findings, we propose the hypothesis that an optimal concentration of CGA confers protection to liver cells via its antioxidant properties

As mentioned above, any thiol group found in a protein is a potential target for E + Hg

Additionally, several studies observed that high concentrations of H 2 showed reduced benefits in certain plants, which might be attributed to the different sensitivity of different plants to H 2 (Li et al., 2021b)