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Histidine can also undergo photo-oxidation

Chronic inflammation promotes neuropathology, including accelerated brain aging, increased risk of developing psychiatric disorders, and cognitive decline 85

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A six-month study using 2g/day found substantial decreases in HbA1c (-0.623) and triglycerides (-31.39) [31]

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Similarly, dietary approaches that increase NO precursors or mitigate oxidative stress (such as dietary nitrate, CIT/L-arginine, and antioxidant polyphenols) can improve exercise-induced enhancements in endothelial function and microvascular blood flow, thereby augmenting substrate delivery to trained musculature and enhancing training responsiveness in geriatric populations (81)