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The de novo synthesis of BH4 occurs through three steps

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Biochem J 473(7):805825 Davin LB, Lewis NG (2000) Dirigent proteins and dirigent sites explain the mystery of specificity of radical precursor coupling in lignan and lignin biosynthesis

Xiao et al., 2012) Briefly, mice were fed with on rodent chow containing 0.2% (w/w) cuprizone (bis-cyclohexanone oxaldihydrazone, Sigma #14690-100G) for different durations up to 5 weeks before sampling for the detection of demyelination and tracing of the OL lineage cell dynamics in the demyelination courses

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Key circRNAs can participate in testis development or spermatogenesis (Xiong et al., 2019)