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Conversely, essential nutrients can mitigate heavy metal toxicity through antagonistic mechanisms

Upon zinc binding, MTF-1 undergoes a conformational change that facilitates its nuclear translocation and binding to MREs in the promoter regions of target genes [146]

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It has been demonstrated that the redox potential of GSH, in contrast to antioxidants without sulfhydryl groups (e.g., vitamin C) [71], modulates Th1/Th2 immune response in T cells as well as in the antigen-presenting cells, i.e., macrophages, dendritic cells, and B cells [65,71,72]

doi:10.1038/onc.2015.32 Lrincz T, Jemnitz K, Kardon T et al (2015) Ferroptosis is involved in acetaminophen induced cell death

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