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(Streatfeild et al., 2021)

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We also observed significantly altered mitochondrial respiratory parameters in the METH-treated hearts indicating defects in mitochondrial respiration occur in an early stage of METH treatment (Supplementary Fig

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28,29 CD4+ helper T cells play an important role in stimulating and maintaining CD8+ T cell response, and insufficient CD4+ helper T cell response is strongly associated with impairment of CD8+ T cell function and viral persistence